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Abstract
Systemic lupus erythematosus (SLE) is associated with immune changes that resemble those seen in normal aging.
- Immunological alterations in SLE include telomere shortening and chronic low-grade inflammation.
- Thymic dysfunction and the expansion of senescent immune cell subsets are observed in SLE.
- Age-associated immune changes may emerge early and are linked to disease activity and organ damage.
- Immunosenescence is connected to complications such as cardiovascular issues, frailty, increased infections, and cognitive impairment in SLE.
- Therapies targeting pathways related to senescence may offer new treatment strategies for SLE.
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