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Approches d’immunothérapie cellulaire T dans les tumeurs solides
T cell immunotherapy for solid tumors
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Abstract
Adoptive T cell therapies for solid tumors include tumor infiltrating lymphocytes (TILs), chimeric antigen receptor (CAR) engineered T cells, and T cell receptor (TCR) engineered T cells.
- TILs are amplified in vitro before being reinjected into patients.
- CAR engineered T cells are designed to target specific cancer cells.
- TCR engineered T cells are modified to recognize specific tumor antigens.
- Challenges such as optimal target selection and the tumor microenvironment may affect treatment outcomes.
- Each therapeutic strategy has its own advantages and disadvantages.
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