NeuropsychologyAug 31, 2026

Reduced brain filtering of sounds linked to mental fatigue in long COVID

Long Covid Weekly Brief ↗PubMed ↗DOI ↗OA ↗

Updated Sep 1, 2026

Abstract

Objective neurophysiological markers for fatigue in long COVID are currently scarce.

Fatigue is a prominent symptom in neurological and postinfectious conditions, particularly in long COVID.
Auditory sensory gating, measured by P50 suppression, is linked to cognitive fatigue in multiple sclerosis.
The relevance of P50 suppression in long COVID remains uncertain.
The Beck Depression Inventory-II and Beck Depression Inventory-Fast Screen (BDI-FS) were compared for their effectiveness in assessing fatigue.

Simplified

Fatigue is among the most disabling symptoms across neurological and postinfectious conditions and is a defining feature of long COVID, yet objective neurophysiological markers remain scarce. Auditory sensory gating, indexed by P50 suppression, has been proposed as a correlate of cognitive fatigue in multiple sclerosis, but its relevance in long COVID is unclear. Additionally, we compared the utility of the Beck Depression Inventory-II and Beck Depression Inventory-Fast Screen (BDI-FS) in this fatigued population.

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Reduced brain filtering of sounds linked to mental fatigue in long COVID

Abstract

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