Reduced protein balance in aging skeletal muscles

Aging is associated with disruptions in the proteostasis network that affects skeletal muscle function.

• Skeletal muscle experiences functional impairment and loss of mass as early age-related changes.
• Disruption of the ubiquitin-proteasomal system (UPS) and autophagy-lysosomal system (ALS) is common in aging tissues.
• Increased oxidative stress contributes to the accumulation of protein aggregates during aging.
• The UPS and ALS pathways are crucial for removing misfolded proteins and damaged organelles.
• Understanding the relationship between proteostasis loss and skeletal muscle aging may clarify the impact of redox regulation on muscle function.

Simplified