Improved Structure and Function in Early-Detected Second-Eye Neovascular Age-Related Macular Degeneration

Of 431 participants, 100 developed neovascular age-related macular degeneration (nAMD) in the second eye at a mean of 18.9 months after initial diagnosis.

• Visual acuity was 18 letters better in the second eye at early diagnosis compared to the first eye (72.9 vs. 55.6 letters).
• Visual acuity remained superior in the second eye 24.9 months postconversion (69.5 letters) compared to the first eye (59.7 letters).
• A higher percentage of participants achieved vision greater than 70 letters in the second eye (61) compared to the first eye (35) 24.9 months postconversion.
• The prevalence of subretinal hyperreflective material and intraretinal fluid was lower in the second eye compared to the first eye 24.9 months postconversion.
• However, the prevalence of subretinal fluid was greater in the second eye 24.9 months postconversion.
• Mean composite quality of life scores improved over time, with a significant correlation between visual acuity in the second eye 24.9 months postconversion.

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