International journal of dentistryOct 15, 2026

Cell Growth, Bone Formation, and New Blood Vessel Growth Triggered by Modified mRNA for a Blood Vessel Growth Protein

mRNA Technology Weekly Brief ↗PubMed ↗DOI ↗OA ↗

Updated Oct 16, 2026

Abstract

Pseudouridine-modified mRNA encoding vascular endothelial growth factor (VEGF) -A may induce VEGF production in human periodontal ligament cells (PDLCs).

VEGF production is potentially influenced by pseudouridine-modified mRNA in PDLCs.
The study evaluates effects on cell proliferation and osteogenic differentiation of PDLCs.
In vivo angiogenesis is assessed as a potential outcome of the treatment.

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