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Abstract
Transient in vivo expression of the four Yamanaka factors induces partial reprogramming in mouse hepatocytes, enhancing liver regenerative capacity.
- Partial reprogramming is associated with reduced levels of differentiated liver cell markers.
- Increased expression of proliferation markers and chromatin modifiers is observed following 4F expression.
- Global changes in DNA accessibility occur alongside the reprogramming process.
- Markers typical of liver stem and progenitor cells are acquired during the reprogramming.
- Short-term expression of 4F enhances liver regeneration through a mechanism involving topoisomerase2.
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