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The incretin hormones glucagonlike peptide 1 and glucose‐dependent insulinotropic polypeptide are neuroprotective in mouse models of Alzheimer's disease
The hormones GLP-1 and GIP may protect brain cells in mouse models of Alzheimer's disease
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Abstract
Liraglutide, lixisenatide, and D-Ala2-GIP cross the blood-brain barrier and show multiple beneficial effects in a mouse model of Alzheimer's disease.
- These incretin mimetics prevent memory formation impairment and enhance synaptic plasticity.
- They increase the number of synapses and reduce the load of amyloid plaques and soluble amyloid-β levels.
- Oxidative stress and chronic inflammation in the brain are reduced with these treatments.
- The proliferation of neuronal progenitor cells is enhanced, resulting in increased neurogenesis in the dentate gyrus.
- Liraglutide treatment normalizes glucose metabolism in forebrain areas, indicating restored neuronal metabolic activity.
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