Boosting weight loss from incretin hormones by increasing energy use

Incretin-based therapies safely reduce food intake and lower body weight, but compensatory drops in basal metabolic rate may hinder sustainable weight loss.

• Energy expenditure (EE) stimulation is being explored to enhance the effects of current weight loss therapies.
• Glucagon receptor agonism has shown potential in promoting a multipronged increase in EE.
• Compensatory challenges in weight loss outcomes persist despite advancements in therapies.
• Peripheral mechanisms can potentially increase EE without the need for physical activity.
• Central mechanisms play a key role in controlling the interplay between EE pathways.

Simplified