Full text is available at the source.
Abstract
Incretin mimetics may lead to significant losses in lean soft tissue, with evidence from 6 studies indicating this outcome.
- Incretin mimetics are associated with weight reduction and improvements in cardiovascular health and quality of life.
- Older adults may experience accelerated losses in skeletal muscle mass and bone mineral density.
- The effects of incretin mimetics on muscle and bone in older adults remain unclear.
- Several trials show significant losses in lean soft tissue and/or bone indices, but the clinical implications for physical function and fragility fracture risk are uncertain.
- A clearer understanding of the impact of incretin mimetics on older adults with obesity is needed for informed clinical decisions.
Simplified