A review on recent developments of indole-containing antiviral agents

Dec 3, 2014European journal of medicinal chemistry

Recent advances in antiviral drugs containing indole

AI simplified

Alzheimers & Treatments on OpenScience ↗PubMed ↗DOI ↗

Abstract

There are seven indole-containing commercial drugs in the Top-200 Best Selling Drugs by US Retail Sales in 2012.

Indole derivatives can mimic peptide structures and bind reversibly to enzymes.
This property may facilitate the discovery of novel drugs with diverse modes of action.
The review provides a comprehensive listing of indole antiviral agents, including those on the market and in clinical trials.
Recent developments in indole compounds and their antiviral activities are summarized, including structural properties.
Perspectives on future exploitation of indole scaffolds as a privileged structure are discussed.

AI simplified

Indole represents one of the most important privileged scaffolds in drug discovery. Indole derivatives have the unique property of mimicking the structure of peptides and to bind reversibly to enzymes, which provide tremendous opportunities to discover novel drugs with different modes of action. There are seven indole-containing commercial drugs in the Top-200 Best Selling Drugs by US Retail Sales in 2012. There are also an amazing number of approved indole-containing drugs in the market as well as compounds currently going through different clinical phases or registration statuses. This review focused on the recent development of indole derivatives as antiviral agents with the following objectives: 1) To present one of the most comprehensive listings of indole antiviral agents, drugs on market or compounds in clinical trials; 2) To focus on recent developments of indole compounds (including natural products) and their antiviral activities, summarize the structure property, hoping to inspire new and even more creative approaches; 3) To offer perspectives on how indole scaffolds as a privileged structure might be exploited in the future.

Full Text

We can’t show the full text here under this license. Use the link below to read it at the source.

View full text (XML) ↗View full text ↗

A review on recent developments of indole-containing antiviral agents

Abstract

Full Text

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the alzheimers & treatments brief

Abstract

Full Text

Related papers

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the alzheimers & treatments brief