Inflammaging in geriatric liver disease: Mechanistic insights and therapeutic frontiers

Chronic liver disease in older adults may be driven by a mechanism termed hepatic 'inflammaging.'

• Hepatic 'inflammaging' is characterized by a chronic, low-grade inflammatory state linked to liver pathology in aging.
• Hepatocellular senescence leads to the secretion of factors that activate immune cells, creating self-sustaining inflammatory loops.
• Age-related decline in the intestinal barrier contributes to ongoing inflammation by releasing substances like lipopolysaccharides.
• The NLRP3 inflammasome plays a key role in integrating stress and metabolic dysfunction, further promoting inflammation.
• Pathological changes in the liver include oxidative stress, fibrogenesis, and impaired regeneration.
• Potential therapies, such as senolytic CAR-T cells and inflammasome inhibitors, have shown promise in preclinical mouse studies but require validation in humans.

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