Crosstalk between inflammation and autophagy in CeD organoids

Increased levels of markers related to impaired autophagic flux and inflammation were observed in celiac disease (CeD) biopsies and organoids compared to controls.

• Celiac disease is associated with mucosal inflammation and villous atrophy in genetically predisposed individuals.
• Alterations in autophagy and inflammatory signaling were identified in the intestinal epithelium of CeD patients.
• In biopsies and organoids from gluten-containing and gluten-free diets, markers indicative of impaired autophagy and mTOR pathway activation were elevated.
• The treatment of control organoids with culture medium from gluten-containing diet CeD organoids reduced autophagic flux and increased inflammation.
• Findings suggest a complex interaction between autophagy and inflammation in the intestinal mucosa of CeD patients.

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