How Inflammation and Metabolism Are Linked in Lung Function Impairment with Normal Breathing Ratios: Causes and Possible Treatments

Preserved Ratio Impaired Spirometry (PRISm) is significantly associated with increased all-cause mortality.

• PRISm is characterized by a FEV₁/FVC ratio &#x2265; 0.7 and FEV₁ < 80% of the predicted value.
• The 'inflammatory-metabolic axis' is proposed as the central mechanism driving PRISm.
• Inflammaging may create a pro-inflammatory environment that, when amplified by external factors, leads to chronic inflammation.
• Metabolic dysfunction could interact with inflammation through oxidative stress and abnormal signaling from fat-derived molecules.
• PRISm may represent an early sign of broader systemic inflammatory and metabolic dysregulation.
• Targeting the interactions between inflammation and metabolism might help in the early identification and intervention for PRISm.

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