Inhalable Metal–Organic Frameworks: A Promising Delivery Platform for Pulmonary Diseases Treatment

Jan 14, 2025ACS nano

Breathable Metal-Organic Frameworks as a New Way to Deliver Medicines for Lung Diseases

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Abstract

Metal-organic frameworks (MOFs) may improve drug delivery efficiency to the lungs for treating respiratory diseases.

Inhalation delivery enables direct administration of drugs to the lungs but struggles with maintaining effective concentrations over time.
MOFs possess customizable porous structures and high surface areas, which could enhance drug retention and release in the lungs.
The integration of MOFs into inhalation therapy may address challenges faced by traditional delivery methods.
Recent advancements in the use of MOFs for inhalable drug formulations show potential in improving treatment outcomes for lung diseases.
Future prospects may include translating the use of inhalable MOFs into clinical applications for respiratory disease management.

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Inhalation delivery, offering a direct pathway for administering drugs to the lungs in the form of dry powders or aerosols, stands out as an optimal approach for the localized treatment of pulmonary diseases. However, the intricate anatomical architecture of the lung often poses challenges in maintaining effective drug concentrations within the lungs over extended periods. This highlights the pressing need to develop rational inhalable drug delivery systems that can improve treatment outcomes for respiratory diseases. Metal-organic frameworks (MOFs) assembled from inorganic metal ions and organic ligands, characterized by customizable porous architecture and chemical composition, modifiable porosity, vast surface area, straightforward surface modification, and adjustable biocompatibility, have garnered extensive attention in the biomedical sphere. The introduction of MOFs into inhalation therapy represents a promising avenue to navigate past the hurdles associated with traditional inhalation methods. Therefore, this review summarizes the characteristics of inhalation delivery together with the latest advances, challenges, and opportunities in utilizing inhalable MOFs for treating lung diseases and discusses prospects in this field alongside the potential pathways for translating this strategy into clinic.

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Inhalable Metal–Organic Frameworks: A Promising Delivery Platform for Pulmonary Diseases Treatment

Abstract

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