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Engineering an Injectable Scaffold with Enhanced ECM Mimicry for Cell Delivery and Tissue Regeneration
Designing an Injectable Support That Better Mimics Natural Tissue for Delivering Cells and Repairing Tissue
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Abstract
CHyCoGel, a novel injectable hydrogel scaffold, supports high cell viability and promotes significant wound healing.
- CHyCoGel is composed of chitosan, hyaluronic acid, chondroitin sulfate, and an amphiphilic stabilizer.
- Primary dermal fibroblasts isolated from neonatal rat skin exhibit well-organized cytoskeletal structures when grafted into CHyCoGel.
- Gene modulation related to tissue remodeling is observed, including increased expression of α-SMA, fibronectin, Col1A1, and TGF-β.
- Application of PDF-loaded CHyCoGel enhances wound healing, epithelialization, and the regeneration of skin appendages.
- CHyCoGel promotes angiogenesis by upregulating VEGF and supports balanced remodeling through enhanced type I collagen expression.
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Key numbers
12
Wound Closure Rate Increase
Total healing score for group in histological scoring.
39.3 ± 5.3
Collagen I Expression
Collagen I levels in skin tissue from -treated wounds.
100%
PDF Viability
Cell viability of grafted PDFs in after 72 hours.