Modulation of an innate immune response by soluble yeast β-glucan prepared by a heat degradation method

Yeast β-glucan was effectively solubilized by treatment at 135°C for several hours.

• Solubilized yeast β-glucan demonstrated antagonistic activity against reactive oxygen production and cytokine synthesis in macrophages.
• The solubilized form strongly reacted with anti-β-glucan antibodies found in human sera.
• Dectin-1, an immune receptor for β-glucan, was also engaged by the solubilized yeast β-glucan.
• Heat degradation may be a significant method for producing soluble yeast β-glucan with immune-modulating properties.

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