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Human innate lymphoid cells
Human natural immune cells involved in early defense
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Abstract
Innate lymphoid cells (ILCs) are categorized into three groups based on their distinct patterns of cytokine production.
- Group 1 ILCs (ILC1s) produce interferon γ and depend on the transcription factor Tbet.
- Group 2 ILCs (ILC2s) produce type 2 cytokines such as interleukin-5 and IL-13, requiring GATA3 for their development.
- Group 3 ILCs (ILC3s), which include lymphoid tissue inducer cells, produce IL-17 and/or IL-22 and depend on the transcription factor RORγt.
- ILCs play critical roles in innate immunity and tissue remodeling, but uncontrolled activation can contribute to inflammatory autoimmune diseases.
- The overview focuses on human ILCs, with references to mouse studies to clarify aspects of ILC biology.
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