Insomnia in seasonal affective disorder: considering the use of benzodiazepines with a focus on lormetazepam

📖 Top 20% JournalJan 30, 2026Frontiers in psychiatry

Insomnia in seasonal depression and the use of benzodiazepines, focusing on lormetazepam

AI simplified

Circadian Biology on OpenScience ↗PubMed ↗DOI ↗OA ↗

Abstract

Insomnia associated with seasonal affective disorder (SAD) may significantly impact quality of life.

Seasonal affective disorder can manifest in winter-pattern or summer-pattern forms, impacting mood during specific seasons.
Sleep disturbances like insomnia are common in individuals with SAD and can exacerbate emotional symptoms.
Short-term or intermittent use of lormetazepam is suggested as an effective treatment for insomnia linked to SAD.
There is an unmet need for more effective treatments for insomnia associated with SAD.
Clinical evidence indicates potential benefits of using benzodiazepines, particularly lormetazepam, to manage insomnia.

AI simplified

BACKGROUND: Seasonal affective disorder (SAD) occurs in two main forms: winter-pattern SAD, associated with depressive symptoms during shorter, darker days; and summer-pattern SAD, linked to mood disturbances during longer, hotter days. SAD may develop into a chronic condition with recurring depressive episodes. Risk factors for SAD include geographic latitude, age, gender, genetic predisposition, and lifestyle. Sleep disturbances, such as insomnia, hypersomnia, and circadian rhythm disruptions, are common and can amplify emotional symptoms.

OBJECTIVE: This review explores the clinical features and management strategies for insomnia associated with SAD, focusing on the potential of benzodiazepines (BZDs), in particular lormetazepam.

RESULTS: Controversies surround current nonpharmacological and pharmacological strategies for managing sleep disorders in SAD. This review emphasizes the importance of using more effective treatments for insomnia associated with SAD, currently an unmet need. In particular, clinical evidence supports the potential benefits of intermittent hypnotic BZDs to treat insomnia. Among the BZDs, short-term or intermittent use of lormetazepam is an effective treatment option in the management of insomnia.

CONCLUSION: Insomnia associated with SAD is an important symptom to monitor because it impacts the patient's quality of life. BZDs, including lormetazepam, are a standard short-treatment option for insomnia that could improve the sleep symptoms associated with SAD. Comparative clinical trials of the efficacy and safety of lormetazepam in this patient population are required to confirm this.

Full Text

Full text is available at the source.

View full text ↗