Genes to cells : devoted to molecular & cellular mechanisms

Insulin's possible role in resetting the body's peripheral biological clocks

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

Insulin may phase-shift or amplify circadian rhythms in human hair follicles.

  • Circadian rhythms in hair follicles are influenced by external cues like light and food.
  • Insulin is rapidly secreted in response to feeding and may affect peripheral clocks such as those in the liver and adipose tissue.
  • Insulin treatment in cultured human hair follicles resulted in phase-responsive changes in clock gene expression.
  • Similar effects of insulin on clock gene expression were observed in whisker follicles from mice, supporting the findings in humans.
  • These results suggest that feeding-induced insulin could play a role in resetting peripheral circadian clocks.

Simplified

Full Text

Full text is available at the source.
View Full Text ↗

Related papers

Mar '15
Oxyntomodulin helps reset the liver's daily clock based on eating
top 2% journal
cited by 91 papers
research support, non-u.s. gov't
Jul '17
Strong syncing of body clocks by steroid hormone injections in genetically modified mice
cited by 22 papers
research support, non-u.s. gov't
Jan '17
Insulin levels during feeding cycles have limited impact on body clocks outside the liver, with different effects from natural versus injected insulin
top 30% journal
cited by 21 papers
research support, non-u.s. gov't
Oct '14
Feeding and stress signals together keep body clocks in sync in mice under different day lengths
cited by 19 papers
research support, non-u.s. gov't
Oct '15
Constant Light Disrupts Body's Daily Rhythms Outside the Brain, Partly Restored by Timed Eating or Exercise
cited by 49 papers
research support, non-u.s. gov't
Apr '16
Exercise changes body clock timing depending on feeding schedule in mice
cited by 22 papers
journal article
Mar '10
Feeding quickly resets the liver’s daily clock by rapidly increasing Per2 and Dec1 gene activity in rats
cited by 36 papers
research support, non-u.s. gov't
May '15
Daily patterns of movement, eating, and liver clock gene activity differ in mice fed alcohol long-term
cited by 17 papers
research support, n.i.h., extramural
Aug '19
Angptl8 helps reset the liver’s daily clock in mice based on food timing
top 2% journal
cited by 66 papers
research support, non-u.s. gov't

what lands in your inbox each week:

  • 📚7 fresh studies
  • 📝plain-language summaries
  • ✅direct links to original studies
  • 🏅top journal indicators
  • 📅weekly delivery
  • 🧘‍♂️always free

Recent issues from the circadian biology brief

issue #44
Sleeping late on weekends is independently linked to higher cardiovascular disease risk
yesterday7 studies
issue #43
A smartphone app cut mood episode recurrence 3.4x in people with depression and bipolar disorder
1 week ago7 studies
issue #42
Morning cancer immunotherapy linked to 49% vs 40% disease control rate in 969 patients
2 weeks ago7 studies
issue #41
Timing cancer treatment before 3pm nearly doubled survival in lung cancer patients
3 weeks ago7 studies
issue #40
Male mice lived 12% longer when they ate only during an 8-hour window at night
4 weeks ago7 studies
issue #38
Emergency doctors had 67% higher odds of chronic pain when working evening shifts vs. morning shifts
6 weeks ago7 studies
issue #36
Night owls show 77% higher risk of job burnout among firefighters
8 weeks ago7 studies
issue #35
Bacteria exposure resets your internal clock independently of immune responses
9 weeks ago7 studies
issue #34
Night owl teens got 47 minutes more sleep with bright light glasses
10 weeks ago7 studies
issue #33
Working out at your optimal time cuts blood pressure twice as much
11 weeks ago7 studies
explore the archive
See more issues from the circadian biology brief