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Abstract
Elevated uPAR expression is linked to cancer, inflammation, and metabolic dysfunction.
- In obesity and aging, increased uPAR levels are associated with chronic inflammation and systemic metabolic disturbances.
- uPAR modulates the differentiation of fat cells and contributes to the progression of inflammatory obesity.
- It acts as a key regulator of cellular aging influenced by factors such as chemotherapy and aging.
- A nanoparticle-based therapy was developed to enhance the delivery of senolytic agents specifically to uPAR-overexpressing cells.
- Co-encapsulated dasatinib and quercetin in these nanoparticles may selectively eliminate senescent cells and reduce inflammation.
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