The role of necroptosis, a type of programmed cell death, in traumatic brain injury

Traumatic brain injury (TBI) involves complex mechanisms, with necroptosis identified as a key driver of secondary injury.

• Necroptosis is a form of programmed cell death that does not involve caspases and is associated with inflammation.
• RIPK1, RIPK3, and MLKL are critical mediators in the necroptosis pathway following TBI.
• The interactions between necroptosis and other forms of programmed cell death, such as apoptosis and autophagy, are not fully understood.
• Understanding these interactions may inform future therapeutic strategies for TBI.
• Comprehensive exploration of necroptosis and its regulatory relationships with other pathways is necessary for effective treatment development.

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