Integrative Dermatology for Longevity: The Synergy of Topical and Internal Approaches

Apr 2, 2026Dermatology and therapy

Combining Skin Treatments and Internal Care to Support Longer Life

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Longevity & Aging on OpenScience ↗PubMed ↗DOI ↗OA ↗

Abstract

Skin aging involves both intrinsic decline and extrinsic factors such as ultraviolet (UV) radiation and air pollution.

The skin exposome includes various influences like psychosocial stress, fatigue, and lifestyle behaviors.
These factors contribute to cumulative damage at the molecular and structural levels in the skin.
An integrative 'In and Out' approach combines topical treatments with internal nutraceuticals targeting aging hallmarks.
This dual-modality model may enhance skin regeneration and improve overall health span.
Emerging tools, including skin aging clocks and AI-guided interventions, could support personalized strategies for longevity.

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Skin aging reflects both intrinsic biological decline and extrinsic influences collectively known as the skin exposome, including ultraviolet (UV) radiation, air pollution, psychosocial stress, fatigue, sleep disruption, and suboptimal lifestyle behaviors. These factors contribute to cumulative molecular and structural damage, positioning the skin as both a visible marker of whole-body aging and a target for longevity strategies. This review examines the validity of an integrative "In and Out" approach, combining topical treatments, such as retinoids, peptides, antioxidants, and exosome-based formulations, with internal nutraceuticals including NADprecursors, collagen peptides, polyphenols, and microbiome modulators. By targeting key hallmarks of aging, oxidative stress, inflammation, and epigenetic changes, this dual-modality model has the potential to promote skin regeneration, enhance aesthetic and functional outcomes, and contribute to broader health span optimization. Emerging tools such as skin aging clocks, biomarker-driven personalization, and artificial intelligence (AI)-guided interventions further strengthen this paradigm, establishing a scientifically grounded, preventive, and personalized framework that redefines the role of dermatology in the context of longevity. Personalized strategies that integrate diagnostic tools, lifestyle coaching, and tracking technologies allow for adaptive, dynamic strategies both internally and externally. +

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Integrative Dermatology for Longevity: The Synergy of Topical and Internal Approaches

Abstract

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