Integrative Migraine Management Within a Healthcare System Part 2: Behavioral, Complementary and Neuromodualtion Approaches

Apr 4, 2026The American journal of medicine

Managing Migraines with Behavioral, Alternative, and Nerve Stimulation Methods in Healthcare

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Abstract

Migraine is the leading cause of disability among adults under the age of 50.

Migraine is associated with various factors such as stress, sleep, diet, and activity that contribute to its burden.
Comorbidities involving the gastrointestinal, cardiovascular, and immunological systems may worsen migraine disability.
An integrative medicine approach could provide comprehensive care by addressing multiple contributing elements.
Behavioral, complementary, and neuromodulation approaches are reviewed as part of an integrative healthcare model.
Emerging therapies like digital interventions and gut-brain axis modulation may represent new directions in migraine care.

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Migraine is a prevalent and disabling neurological condition that benefits from multimodal care. While a growing number of migraine therapies have become available, migraine remains the leading cause of disability among adults under the age of 50. The unmet burden of migraine is likely due to several elements such as stress, sleep, diet, and activity. Additionally, comorbidities involving the gastrointestinal, cardiovascular, and immunological systems can often worsen migraine disability. An integrative medicine approach has potential to synergistically address these elements while providing whole person migraine care. In Part 1 of this article, we provided an overview of migraine and updates on pharmacological and procedural care. This section, Part 2, reviews evidence-based behavioral, complementary, and neuromodulation approaches for migraine within an integrative healthcare model. Emerging therapies, including digital interventions and gut-brain axis modulation, highlight evolving directions in care. An integrative, patient-centered approach that combines these modalities within coordinated healthcare systems may improve outcomes, enhance quality of life, and reduce long-term burden for individuals with migraine.

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Integrative Migraine Management Within a Healthcare System Part 2: Behavioral, Complementary and Neuromodualtion Approaches

Abstract

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