Intelligent Hierarchical Hydrogel Architectures Integrating Photothermal Conversion, Self-Healing, Bioadhesion and Antibacterial Activity for Next-Generation Wound Management

Oct 8, 2025Biomacromolecules

Smart Layered Hydrogels Combining Heat Response, Self-Healing, Stickiness, and Antibacterial Properties for Advanced Wound Care

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Regenerative Health on OpenScience ↗PubMed ↗DOI ↗

Abstract

The novel DAPEG/GAEPL@TA/Fe hydrogel significantly accelerated wound healing in vivo.

The hydrogel exhibited strong wet adhesion and excellent mechanical properties.
Antibacterial effects were enhanced by photothermal conversion under NIR irradiation, inhibiting both Gram-positive and Gram-negative bacteria.
Remarkable hemostatic performance was observed in mouse models.
Wound healing was associated with enhanced collagen deposition and reduced inflammation.

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Effective wound management remains a significant challenge in healthcare, necessitating advanced materials that can address multiple limitations of wound healing simultaneously. Herein, we developed a novel mfp5-inspired and multicross-linked hydrogel (DAPEG/GAEPL@TA/Fe) incorporating dibenzaldehyde-terminated polyethylene glycol, ε-poly-l-lysine, gallic acid, tannic acid, and Feions. Physicochemical properties of the hydrogel, antibacterial efficacy, hemostatic capabilities, and wound healing performance were extensively assessed by means of in vitro and in vivo investigations. The DAPEG/GAEPL@TA/Fe hydrogel demonstrated strong wet adhesion, excellent mechanical properties, and self-healing capabilities. Its antibacterial efficacy was enhanced by photothermal conversion under NIR irradiation, effectively inhibiting both Gram-positive and Gram-negative bacteria. The hydrogel showed remarkable hemostatic performance in mouse models and significantly accelerated wound healing in vivo, with enhanced collagen deposition and reduced inflammation. The multifunctional DAPEG/GAEPL@TA/Fe hydrogel embodies a breakthrough in wound dressing materials, offering a comprehensive solution for complex wound management challenges. Its unique combination of properties and demonstrated efficacy suggest promising potential for clinical utilization in wound management and tissue regeneration. 3+

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Intelligent Hierarchical Hydrogel Architectures Integrating Photothermal Conversion, Self-Healing, Bioadhesion and Antibacterial Activity for Next-Generation Wound Management

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