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Abstract
Advanced parental age is associated with increased risks of congenital anomalies and neurodevelopmental dysfunction in offspring.
- Advanced parental age (APrA) is defined as 35 years or older for mothers and 40 years or older for fathers.
- APrA may impact offspring healthspan, leading to a higher likelihood of premature mortality.
- Children of older parents could face increased risks of metabolic dysfunction.
- There is a potential link between APrA and neurodegenerative diseases in descendants.
- APrA supports the concept of an 'intergenerational clock' that connects reproductive timing with aging patterns in future generations.
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