A network meta‐analysis for the comparison of efficacy and safety of interleukin (IL)‐23 targeted drugs in the treatment of moderate to severe psoriasis

Jun 11, 2020Dermatologic therapy

Comparing the effectiveness and safety of IL-23 targeting drugs for moderate to severe psoriasis

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Abstract

A network meta-analysis of 14 randomized controlled trials involving 8402 patients found that risankizumab offers superior short-term efficacy for treating moderate to severe psoriasis compared to other interleukin-23 targeted drugs.

Risankizumab at 90 mg and 180 mg demonstrated significantly better efficacy than tildrakizumab, ustekinumab, and guselkumab in achieving treatment goals.
Risankizumab ranked highest for achieving a 75% reduction in psoriasis severity (PASI 75) and a Physician Global Assessment score of 0 or 1 (PGA 0/1).
The analysis indicated no significant difference in the risk of adverse events between IL-23 targeted drugs and placebo.
Risankizumab 90 mg had a SUCRA value of 97.6%, indicating the best efficacy for PASI 75, while 180 mg ranked first for PASI 90 (91.1%).
Risankizumab 75 mg had the best performance for the Dermatology Life Quality Index of 0 or 1 (DLQI 0/1) with a score of 73.7%.

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A variety of interleukin-23 targeted drugs have been used to treat moderate to severe psoriasis, but it is not clear which is most effective. This network meta-analysis compared and summarized the short-term efficacy and safety of interleukin-23 (IL-23) targeted drugs in the treatment of moderate to severe psoriasis. PubMed, Embase, Web of Science, and Cochrane Library were used to search randomized controlled trials (RCTs) about the treatment of moderate to severe psoriasis with ustekinumab (Ust), guselkumab (Gus), tildrakizumab (Til), and risankizumab (Ris). Bayesian Network Meta-analysis (NMA) was used to calculate Psoriasis Area and Severity Index 75%, 90%; Physician Global Assessment score of 0 or 1 (PGA 0/1); Dermatology Life Quality Index of 0 or 1 (DLQI 0/1), and safety (adverse events [AEs]) effect estimates (odds ratio OR) and 95% confidence intervals. Direct, indirect, and network meta-analysis estimates were calculated using a random-effects model. The GRADE method was used to assess the quality of evidence for each pair-wise comparison. In addition, the surface under the cumulative ranking curve (SUCRA) analysis was used to rank the treatment level for each outcome indicator. This network meta-analysis included 14 RCTs with 8402 patients. The results indicate that the curative effect of the IL-23 targeted drugs is better than that of a placebo. Network meta-analysis showed that Ris90 mg and Ris180 mg were significantly more effective than Til (5, 25, 100, and 200 mg), Ust (45 mg, 90 mg, body weight-based administration), Gus 100 mg and Ris (75 and 150 mg). Regarding safety, there is no significant difference in the risk of adverse events between drugs targeting IL-23 and placebo. In addition, according to the ranking of SUCRA, Ris 90 mg has the best efficacy index for PASI 75 and PGA 0/1, with SUCRA values of 97.6% and 97.1%, respectively. Ris 180 mg ranked first in PASI 90 (91.1%), while Ris 75 mg performed best in DLQI 0/1 (73.7%). In this network meta-analysis, risankizumab showed the best curative effect in the short-term treatment of moderate to severe psoriasis, and the risk of adverse events was not significantly different from placebo. However, more research data are needed for further study in the field of cost to evaluate which drug strikes the most favorable balance among efficacy, safety, and cost of access.

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A network meta‐analysis for the comparison of efficacy and safety of interleukin (IL)‐23 targeted drugs in the treatment of moderate to severe psoriasis

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