Bidirectional effect of intestinal microbiome and host in circadian rhythm disruption: Environmental factors and breast cancer development

Disruption of circadian melatonin signaling and gut microbiome imbalances are significant factors associated with increased breast cancer incidence.

• Circadian melatonin signaling amplitude suppression may contribute to breast cancer risk.
• Dietary changes or phase shifts can disrupt the host's circadian clock, potentially influencing cancer development.
• Host-derived mature microRNAs can alter the epigenetic profile of gut microbiota.
• Metabolites from intestinal bacteria may change the profile of host microRNAs.
• Epigenetic interactions between the gut microbiota and the host may activate oncogenic pathways in tissues outside the gut.

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