The Intestinal microenvironment and Disorders of Gut-Brain Interactions

A multitude of factors may confound the identification of a specific microbial 'signature' in Disorders of Gut-Brain Interaction (DGBI).

• Recent data highlights the significant role of gastrointestinal luminal contents in the development of DGBI-related symptoms.
• Alterations in gut microbiome composition have been observed, but a clear microbial signature has not been established.
• The complexities of the gut barrier and its associated immune and hormonal systems are crucial for signaling between the gut and the host.
• The microbiome-gut-brain axis concept has emerged to help explain how symptoms arise in DGBI.
• Recent findings have sparked renewed interest in the interactions between luminal contents and enteric phenomena in DGBI.

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