Intra‐Articular Injectable Biomaterials for Cartilage Repair and Regeneration

Feb 7, 2024Advanced healthcare materials

Injectable Materials for Repairing and Regrowing Joint Cartilage

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Regenerative Health on OpenScience ↗PubMed ↗DOI ↗OA ↗

Abstract

Injectable may enhance drug delivery for cartilage repair in .

Osteoarthritis involves cartilage deterioration and inflammation in the bone.
Injectable hydrogels are being explored for their ability to deliver drugs directly to the cartilage.
Different types of hydrogels, including physically and chemically crosslinked versions, are available for this purpose.
These hydrogels can encapsulate therapeutic agents and release them in a controlled way.
Incorporating growth factors, anti-inflammatory drugs, and cells into hydrogels could improve treatment outcomes.

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is a degenerative joint disease characterized by cartilage deterioration and subsequent inflammatory changes in the underlying bone. Injectable have emerged as a promising approach for controlled drug delivery in cartilage therapies. This review focuses on the latest developments in utilizing injectable hydrogels as vehicles for targeted drug delivery to promote cartilage repair and regeneration. The pathogenesis of osteoarthritis is discussed to provide a comprehensive understanding of the disease progression. Subsequently, the various types of injectable hydrogels used for intra-articular delivery are discussed. Specifically, physically and chemically crosslinked injectable hydrogels are critically analyzed, with an emphasis on their fabrication strategies and their capacity to encapsulate and release therapeutic agents in a controlled manner. Furthermore, the potential of incorporating growth factors, anti-inflammatory drugs, and cells within these injectable hydrogels are discussed. Overall, this review offers a comprehensive guide to navigating the landscape of hydrogel-based therapeutics in osteoarthritis.

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Intra‐Articular Injectable Biomaterials for Cartilage Repair and Regeneration

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