Intra-articular lornoxicam loaded PLGA microspheres: enhanced therapeutic efficiency and decreased systemic toxicity in the treatment of osteoarthritis

Intra-articular injection of Lnxc-loaded PLGA microspheres demonstrated prolonged drug retention in joint tissues.

• The plasma drug concentration decreased after intra-articular injections, indicating effective targeting to joint tissues.
• Retention time of the drug in the joint was increased with the use of microspheres compared to suspensions.
• No signs of filtration liquid accumulation or excessive blood vessel and fibrous proliferation were observed, suggesting good biocompatibility.
• Lnxc-loaded microspheres were associated with repair of articular cartilage damage caused by papain.
• The study indicates potential for Lnxc-loaded PLGA microspheres as a sustained release delivery system for treating osteoarthritis.

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