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Delivery of whole antibodies inside cells using organ-targeted fat-based nanoparticles
Updated
Abstract
A lipid nanoparticle platform can efficiently deliver therapeutic antibodies into cancer cell lines.
- The platform enables selective inhibition of key transcription factors involved in inflammatory and cancer signaling pathways.
- Therapeutic antibodies were successfully delivered systemically in disease models.
- Specific applications included α-synuclein-targeting antibodies for Parkinson's disease and RelA-targeting Immunoglobulins for acute lung injury.
- This method may aid in treating various intracellular disease targets by overcoming delivery challenges.
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mRNA Technology