Journal of the American Chemical Society

Changes in Lipid Nanoparticle Structures Linked to mRNA Delivery in Immune Cells

mRNA Technology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

A novel series of lipid nanoparticles (LNPs) shows a strong correlation between their pH-sensitive structural transitions and macrophage transfection efficiency.

  • LNPs containing ionizable amino-lipids exhibit tunable liquid crystalline mesophases, including cubic and hexagonal phases.
  • The mesophase transition of LNPs during acidification is associated with their ability to effectively transfect lung macrophages.
  • Structural differences between two ionizable lipids, SM-102 and ALC-0315, influence the internal structural transformations of LNPs.
  • SM-102 LNPs demonstrated improved transfection efficiency due to their ability to form a cubic structure at lower pH compared to ALC-0315 LNPs.

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