Current opinion in biotechnology

Using Artificial Intelligence to Improve Ionizable Lipids for mRNA Delivery

Updated

Abstract

Artificial intelligence may enable nearly complete automation of ionizable lipid development processes.

  • Ionizable lipids are crucial for the effective delivery of mRNA in biological systems.
  • Traditional methods for developing ionizable lipids are labor-intensive, costly, and time-consuming.
  • AI can facilitate the synthesis and screening of ionizable lipids, potentially reducing manual effort.
  • Machine learning can predict new ionizable lipids with desirable performance based on existing data.
  • Automating development processes may lead to significant advancements in lipid nanoparticle technologies.

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Funding

Competing interests

Declaration of Competing Interest The authors have no conflicts of interest to declare.
PubMed

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