Journal of controlled release : official journal of the Controlled Release Society

Using special fats with oleic acid and vitamin E to deliver RNA cancer vaccines

Updated

Abstract

The inclusion of vitamin E moieties in lipid nanoparticles significantly enhanced cellular immune responses and suppressed tumor growth in a mouse model.

  • Lipid nanoparticles containing a combination of ionizable lipids were developed to improve vaccine efficacy.
  • The formulation showed enhanced capability to induce cellular immunity in tumor-bearing mice.
  • Robust activation of reactive CD8 T cells was observed, specifically recognizing neoantigens expressed in gastric cells.
  • Tumor suppression was demonstrated in the YTN16 tumor model using the developed lipid nanoparticles.
  • Lipid nanoparticles may serve as a viable platform for RNA-based cancer vaccines.

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Full Text

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Funding

Competing interests

Declaration of competing interest This research was partially conducted as joint research between Tohoku University, Chiba University, and NOF CORPORATION. The remaining funding organizations had no roles in the design, collection, analyses, or interpretation of data for this study. These organizations also had no roles in either the writing of the manuscript or in the decision to publish the results. H.T., Y.N., K.T., and H.A. hold a relative patent pending number WO/2019/188867. H.T., Y.N., K.T., and H.A. hold a relative patent pending number WO/2021/060440. H.T., Y.N., K.T., and H.A., hold a relative patent pending number WO/2023/190170. H.T., J.A., R.O., Y.N., K.T., and H.A., hold a relative patent pending number WO/2024/014511. Y.N. and K.T. are employed by NOF CORPORATION. H.T. and H.A. have received consultant fees from NOF CORPORATION.
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