Beyond IOP: Neuroprotection and neuroregeneration as important therapeutic strategies for glaucoma

Jan 7, 2026Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Protecting and Repairing Nerve Cells as Key Treatments for Glaucoma Beyond Eye Pressure

AI simplified

Regenerative Health on OpenScience ↗PubMed ↗DOI ↗

Abstract

Glaucoma may lead to irreversible blindness through the progressive death of retinal ganglion cells.

Current treatments primarily focus on reducing intraocular pressure, but many patients continue to experience disease progression despite normal IOP.
Key factors associated with glaucomatous neurodegeneration include inflammation, excitotoxicity, mitochondrial dysfunction, oxidative stress, and lack of neurotrophic support.
Pharmaceutical strategies for neuroprotection include glutamate modulators, antioxidants, mitochondrial protectants, and anti-inflammatory drugs.
Nonpharmacological approaches, such as stem cell transplantation, gene therapy, and nanotechnology-based drug delivery systems, may offer long-term neuroprotective benefits.
Most of these strategies are still in preclinical or early clinical phases and require further randomized controlled trials and safety evaluations.

AI simplified

Glaucoma is the leading cause of irreversible blindness characterized by the progressive death of retinal ganglion cells (RGCs) and damage to the optic nerve. Although the main goal of current treatment approaches is to reduce intraocular pressure (IOP), many patients' disease progression persists even after IOP returns to normal, highlighting the urgent need for effective neuroprotective strategies. The pathogenesis of glaucomatous neurodegeneration is thoroughly reviewed in this study, with special attention given to the roles of inflammation, excitotoxicity, mitochondrial dysfunction, oxidative stress, and compromised neurotrophic support. This study examines both pharmaceutical and nonpharmacological neuroprotective strategies while discussing the complex pathophysiology of glaucomatous neurodegeneration. Glutamate modulators, antioxidants, mitochondrial protectants, and anti-inflammatory drugs are examples of pharmacological tactics. Moreover, novel nonpharmacological approaches such as stem cell transplantation, gene therapy, and drug delivery systems based on nanotechnology show promise as long-term neuroprotective strategies. These strategies could increase the number of therapeutic options available for glaucoma by targeting mechanisms other than IOP. However, most of them are still in the preclinical or early clinical stages and need well-designed randomized controlled trials and long-term safety data before they can change standard clinical practice. We conclude by describing potential future paths, such as the need for integrated, patient-centered therapy paradigms, AI-driven prognostic tools, and precision medicine. Overall, this review highlights how crucial neuroprotection is as a developing element in the comprehensive treatment of glaucoma.

Full Text

Full text is available at the source.

View full text (XML) ↗View full text ↗

Beyond IOP: Neuroprotection and neuroregeneration as important therapeutic strategies for glaucoma

Abstract

Full Text

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Abstract

Full Text

Related papers

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week: