Irritability in bipolar disorder and unipolar disorder measured daily using smartphone‐based data: An exploratory post hoc study

Patients with unipolar depressive disorder spent 83.10% of their depressive state experiencing irritability, compared to 70.27% in bipolar disorder.

• Irritability was found to be associated with lower mood, reduced activity levels, and shorter sleep duration in both bipolar and unipolar depressive disorder patients.
• Increased irritability correlated with higher stress and anxiety levels across the two patient groups.
• Higher levels of irritability were linked to impaired functioning and greater perceived stress.
• In patients with unipolar depressive disorder, increased irritability was specifically associated with a decrease in quality of life.
• The findings remained consistent regardless of psychopharmacological treatments.

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