Lancet (London, England)Oct 29, 2026

Irritable Bowel Syndrome and Other Gut-Brain Interaction Disorders

Gut-Brain Axis Weekly Brief ↗PubMed ↗DOI ↗

Updated Nov 2, 2026

Abstract

20% of the global population is affected by irritable bowel syndrome, chronic constipation, and functional diarrhoea.

Symptoms include abnormal stool consistency or frequency, along with abdominal pain, discomfort, bloating, or distension.
Risk factors identified are female sex, younger age, a history of common mental disorders, and acute enteric infection.
The underlying mechanisms involve disordered gut motility and increased sensitivity of the gut to pain.
Diagnosis relies on clinical history, exclusion of alarm symptoms, and targeted investigations.
Management strategies focus on education, dietary adjustments, and symptom-targeted medications, but effectiveness is generally modest.
There is ongoing development of novel drugs to address the limitations of current treatment options.

Simplified

Irritable bowel syndrome, chronic constipation, and functional diarrhoea are disorders of gut-brain interaction, the symptoms of which include abnormal stool consistency or frequency accompanied by varying degrees of abdominal pain, discomfort, bloating, or distension. These conditions affect 20% of the global population with a relapsing and remitting course. Risk factors include female sex, younger age, a history of common mental disorders, and acute enteric infection. The pathophysiology of irritable bowel syndrome, chronic constipation, and functional diarrhoea remain incompletely understood, but are thought to be secondary to aberrant interactions throughout the gut-brain axis, resulting in disordered gut motility and visceral hypersensitivity. These conditions are diagnosed with a combination of clinical history, absence of alarm symptoms-such as weight loss or rectal bleeding-and targeted investigations. An empathetic management approach improves quality of life and symptoms, reduces health-care use, and enhances treatment adherence. Mainstays of treatment include education, dietary and lifestyle advice, modifying fibre intake, and drugs directed towards predominant symptoms. For severe symptoms, other treatments include specific medical devices, biofeedback, or psychological therapies. However, the effectiveness of most treatments is modest and there is an ongoing need to expand available treatments for bowel disorders, with several novel drugs currently in development.

Full Text

Full text is available at the source.

View Full Text ↗

Irritable Bowel Syndrome and Other Gut-Brain Interaction Disorders

Abstract

Full Text

You found one interesting study. We’ll send the next 7.

What Lands in Your Inbox Each Week:

Recent issues from the gut-brain axis brief