Juvenile hormone acid O-methyltransferase in Drosophila melanogaster

Jun 14, 2008Insect biochemistry and molecular biology

Enzyme that modifies juvenile hormone in fruit flies

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Abstract

Overexpression of DmJHAMT in fruit flies leads to a pharate adult lethal phenotype.

  • DmJHAMT is an enzyme that converts farnesoic acid and JH III acid into methyl esters.
  • The gene is predominantly expressed in the corpora allata of Drosophila melanogaster.
  • Developmental expression of DmJHAMT correlates with changes in juvenile hormone levels.
  • Transgenic RNA interference targeting DmJHAMT shows no visible effects on development.
  • Temporal regulation of DmJHAMT is suggested to be critical for proper Drosophila development.

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