The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry

How Ketamine Affects the Brain and Creates Dissociative Experiences

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Abstract

Ketamine is a special anesthetic that can cause people to feel detached from their surroundings. It has been found useful not just for anesthesia but also as a fast-acting treatment for depression. This paper looks at how ketamine affects brain circuits, especially by blocking certain receptors and changing how brain cells communicate. The review discusses new research on how ketamine changes brain activity, potentially even at a cellular level, after just one use. Understanding these effects could help us find new treatments for depression and better understand different states of consciousness.

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Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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