Journal of psychopharmacology (Oxford, England)

Using ketamine with therapy to help people quit smoking: A first test of safety, feasibility, and results

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Abstract

Ketamine may enhance smoking cessation efforts when combined with motivational enhancement therapy.

  • Tobacco use is a major preventable cause of illness and death.
  • Current treatments for tobacco use disorder have only modest effectiveness.
  • Ketamine acts on glutamate receptors and may promote brain adaptability.
  • Combining ketamine with motivational enhancement therapy could support behavioral treatments.
  • This combination may improve cognitive flexibility and psychological resilience in individuals trying to quit smoking.

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