Ketamine and Esketamine for Sudden Suicidal Crises: What We Know, Their Limits, and a New Recovery Approach

Intravenous racemic ketamine and intranasal esketamine may influence outcomes for adults experiencing acute suicidal presentations.

• Evidence synthesis indicates potential effects of intravenous racemic ketamine and intranasal esketamine on acute suicidal presentations.
• Outcomes associated with these interventions are still being evaluated to determine what changes may occur.
• The role of these treatments within a comprehensive emergency suicide-care pathway is under consideration.

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