Ketogenic Diet's Effects on Brain Inflammation in Neurodegenerative Diseases

The ketogenic diet (KD) may benefit neurodegenerative diseases by triggering the production of ketone bodies.

• KD mimics fasting, which helps induce a state of ketosis in the body.
• Studies indicate that KD could positively influence metabolism, mitochondrial function, and inflammation.
• The diet may regulate neuroinflammation through interactions with the gut microbiome and other mechanisms.
• KD is associated with protective effects in normal brain aging and various neurodegenerative diseases, including Alzheimer's, Parkinson's, ALS, and Huntington's disease.
• The review aims to clarify the neuroinflammatory mechanisms linked to KD therapies in neurodegenerative conditions.

Simplified