Monitoring Kleine–Levin Syndrome Recovery Using Human‐Smartphone Interactions: A Digital Phenotyping Approach

Mar 20, 2026Journal of sleep research

Tracking Kleine-Levin Syndrome Recovery Through Smartphone Use Patterns

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Abstract

A 25-year-old male with Kleine-Levin syndrome experienced sleep episodes exceeding 15 hours per day.

  • Episodes included significant behavioral disturbances, such as excessive eating and heightened sexual behavior.
  • Monitoring through a smartphone app revealed inactivity during sleep episodes and structured activity during recovery.
  • Circadian rhythm stability improved from low values during episodes to greater than 0.37 upon returning to full-time work.
  • Digital phenotyping may effectively track functional and circadian changes in individuals with Kleine-Levin syndrome.

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