Investigations on the Prospects of Using Lactiplantibacillus plantarum to Combat Depression through Gut Microbiota–Brain Axis

Gut dysbiosis is associated with negative impacts on mood, cognition, and behavior.

• Depression contributes significantly to disease burden due to higher mortality and prevalence rates.
• The gut microbiota plays a crucial role in mood regulation and may influence the etiology and management of depression.
• Restoring normal gut composition through methods like probiotics may improve therapeutic outcomes for depression.
• Lactiplantibacillus plantarum has emerged as a prominent probiotic strain with potential antidepressant effects.
• Mechanisms by which L. plantarum may regulate depression involve modulation of the gut-brain axis and production of compounds such as GABA and short-chain fatty acids.
• Metabolic engineering and effective delivery strategies for L. plantarum to the brain may enhance its therapeutic potential.

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