Lactoferrin-modified stem cell vesicles help cross the brain barrier and boost gastrodin’s nerve protection in Parkinson’s disease through cell cleanup processes

Gastrodin's neuroprotective efficacy is limited by poor blood-brain barrier permeability.

• The blood-brain barrier significantly restricts the delivery of neuroprotective agents to the brain in Parkinson's disease.
• Gastrodin has recognized neuroprotective properties but struggles to effectively reach the brain.
• A brain-targeted delivery system using extracellular vesicles is being developed to enhance the delivery of gastrodin.
• The study aims to clarify the neuroprotective mechanisms of gastrodin when delivered effectively.

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