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Length polymorphism in the Period 3 gene is associated with sleepiness and maladaptive circadian phase in night-shift workers.
Variation in the Period 3 gene is linked to sleepiness and poor body clock adjustment in night-shift workers
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Abstract
Period 3(-/5) shift workers had significantly lower multiple sleep latency (3.52 ± 23.44 min) compared to Period 3(4/4) workers (10.39 ± 6.41 min, P = 0.003).
- Period 3(-/5) night-shift workers exhibited higher sleepiness levels on the Epworth Sleepiness Scale at 17:00 hours (12.08 ± 2.55) compared to Period 3(4/4) workers (8.00 ± 1.94, P < 0.001).
- Melatonin onset occurred significantly earlier in Period 3(-/5) individuals (20:44 ± 6:37) than in Period 3(4/4) shift workers (02:46 ± 4:58, P = 0.021).
- Regression analysis indicated that Period 3 genotype may independently predict sleepiness, even when accounting for circadian phase variations.
- Period 3(-/5) workers exhibited both subjective and objective sleepiness in the pathological range, while Period 3(4/4) workers maintained sleepiness within normal limits.
- Circadian phase for Period 3(-/5) night workers was on average 6 hours earlier, suggesting a lesser adaptation compared to Period 3(4/4) workers.
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