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Abstract
The Itabaianinha cohort in Brazil exhibits a unique combination of markedly reduced stature and body mass alongside preserved lifespan and healthspan.
- Telomere shortening is linked to cumulative cell replication and serves as a mitotic clock.
- Age and body mass are associated with increased demand for cell proliferation.
- The GH/IGF-I axis is central to the process of cell proliferation.
- Individuals with severe isolated congenital growth hormone deficiency show distinct biological aging patterns.
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