Gene regulation and systems biology

How the Timing of Light and Eating Together Helps Set Strong Body Clocks Outside the Brain

Updated

Abstract

A semimechanistic mathematical model predicts that peripheral clock genes in human liver cells can be completely entrained to feeding rhythms, independent of light/dark cycles.

  • Feeding and fasting cycles serve as significant behavioral signals that synchronize biological rhythms in peripheral organs.
  • Phase misalignment between feeding rhythms and light/dark cycles may lead to circadian disruptions and physiological abnormalities.
  • The model incorporates the effects of light/dark cycles and feeding rhythms on the dynamics of clock genes in liver cells.
  • The activity of sirtuin 1, a cellular energy sensor, is included as a key factor in the model.
  • Different light-feeding phase relationships and intensities were simulated to explore their effects on feeding entrainment mechanisms.
  • The findings suggest that the relationship between light and feeding signals is crucial for maintaining robust circadian rhythms.

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Funding

Competing interests

DECLARATION OF CONFLICTING INTERESTS: The author(s) received no financial support for the research, authorship, and/or publication of this article. Disclosures and Ethics As a requirement of publication, author(s) have provided to the publisher signed confirmation of compliance with legal and ethical obligations including but not limited to the following: authorship and contributorship, conflicts of interest, privacy and confidentiality, and (where applicable) protection of human and animal research subjects. The authors have read and confirmed their agreement with the ICMJE authorship and conflict of interest criteria. The authors have also confirmed that this article is unique and not under consideration or published in any other publication, and that they have permission from rights holders to reproduce any copyrighted material. Any disclosures are made in this section. The external blind peer reviewers report no conflicts of interest.
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