LINC01278 controls changes in human blood vessel muscle cells during aortic dissection by regulating ACTG2 through miR-500b-5p

In a comparison of 6 aortic dissection samples and 6 control samples, linc01278 and ACTG2 were found to be downregulated, while miR-500b-5p was upregulated in aortic dissection tissues.

• Linc01278, microRNA-500b-5p, and ACTG2 are involved in the vascular smooth muscle contraction pathway.
• Molecular markers associated with VSMC phenotypic switching, such as SM22α, SMA, calponin, and MYH11, were downregulated in aortic dissection tissues.
• Overexpression of linc01278 reduced VSMC proliferation and phenotypic switching, while its downregulation had the opposite effect.
• Linc01278 was confirmed to regulate miR-500b-5p, which directly targets ACTG2 in HEK293T cells.
• The linc01278-miR-500b-5p-ACTG2 axis may serve as a basis for developing diagnostic markers and therapeutic targets for aortic dissection.

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